Keynote Speaker · Neuroscience, Leadership & Well-Being

Dr. BlaiseAguirre

  • Psychiatrist
  • Harvard Medical School Faculty
  • Bestselling Author
  • Executive Educator

The science of the mind. The complexity of being human. The power to change how we lead, heal, and live.

Dr. Blaise Aguirre, psychiatrist and keynote speaker, in a dark suit

Neuroscience · Psychiatry · Leadership

A Harvard psychiatrist who makes the science of the mind deeply human — for any room where people lead, perform, care for others, or simply want to live well.

Dr. Blaise Aguirre is a psychiatrist, bestselling author, and faculty member in Harvard Medical School Executive Education. As Founding Medical Director of the 3East DBT Continuum at McLean Hospital and The Michael Hollander, PhD, Endowed Director, he has spent decades working with people experiencing profound emotional suffering while translating neuroscience, psychology, mindfulness, and human behavior into ideas that resonate far beyond the clinical world.

He uses clinical stories, practical skills, humor, and accessible science to help audiences understand their own reactions and respond more effectively — whether the room is filled with executives, healthcare leaders, clinicians, or high-performing teams.

Harvard Medical School Executive Education

His Harvard Medical School executive education program is one of the institution’s most popular non-AI corporate learning offerings.

Why Blaise

Clinical depth. Executive reach.

Credibility with the analytical room and the emotional one.

  • Harvard Medical SchoolExecutive Education Faculty
  • Assistant Professor in PsychiatryHarvard Medical School Department of Psychiatry
  • Founding Medical Director3East DBT Continuum, McLean Hospital
  • The Michael Hollander, PhD, Endowed DirectorMcLean Hospital
  • Bestselling AuthorBooks on self-criticism, DBT, and adolescent mental health
  • International Speaker & ClinicianCorporate, healthcare, association, and education audiences

Signature Keynotes

Three keynotes on how we think, lead, and live.

Each talk blends neuroscience, clinical insight, and practical skills, and each can be shaped around the goals of your audience.

The Neuroscience of Leadership

Understanding the Brain That Leads

How understanding the brain can transform decision-making, emotional intelligence, resilience, and the way we lead.

Through his work with Harvard Medical School Executive Education, Dr. Aguirre makes neuroscience practical, showing how stress, emotion, attention, and different brain systems shape the way leaders handle pressure, navigate uncertainty, connect with others, and lead through change.

Using accessible scientific explanations and relatable organizational analogies, he helps audiences understand why even highly accomplished leaders can become reactive under pressure — and how mindfulness, emotional regulation, and greater awareness of the brain can support more thoughtful leadership.

Key takeaways

  1. Recognizing how stress affects judgment and behavior
  2. Responding more thoughtfully under pressure
  3. Approaching difficult conversations with greater emotional awareness
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The Voice Within

Overcoming Self-Doubt, Imposter Syndrome, and the Inner Critic

Why some of the most accomplished people are also their own harshest critics.

Dr. Aguirre explores why achievement rarely quiets the inner critic and how self-doubt, imposter syndrome, identity, and persistent self-criticism can shape leadership, relationships, performance, and well-being.

Drawing from decades of clinical experience, he examines the difference between constructive self-evaluation and destructive self-criticism, and how mindfulness, emotional awareness, and evidence-based psychological approaches can help people pursue excellence without allowing every outcome to become a verdict on their personal worth.

Key takeaways

  1. Distinguishing constructive self-evaluation from destructive self-criticism
  2. Understanding why achievement does not always resolve self-doubt
  3. Pursuing excellence without making every outcome a verdict on personal worth
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The Science of Well-Being

What Makes a Life Worth Living

Achievement can build a successful life. It cannot, by itself, make that life feel worth living.

After decades spent helping people navigate profound emotional suffering, Dr. Aguirre has learned that well-being is shaped by far more than status, performance, or achievement.

Blending neuroscience, mindfulness, clinical insight, and deeply human stories, he explores what allows people not simply to function, but to flourish. He examines the roles of attention, relationships, purpose, emotional regulation, and our ability to fully experience the lives we are already living.

For high-achieving audiences accustomed to pursuing the next goal, this keynote offers a powerful alternative: learning how to pursue excellence without postponing well-being until after the next accomplishment.

Key takeaways

  1. Understanding why achievement and external success do not automatically create well-being
  2. Using mindfulness to become more present rather than constantly pursuing what comes next
  3. Strengthening the relationships, sense of purpose, and emotional skills that help create a life worth living
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Portrait of Dr. Blaise Aguirre in a light blue sweater

Beyond the three keynotes

Tailored for the Room

Blaise’s talks adapt to each audience and event.

For organizations navigating leadership, neuroscience, well-being, innovation, human behavior, patient care, or emotional health, elements of multiple talks can be combined into a customized keynote, executive session, workshop, or conversation.

His breadth of expertise allows each engagement to meet both the intellectual and emotional needs of the room.

Custom healthcare and clinical topics are also available.

Discuss a custom engagement

Watch Blaise

Selected Conversations

From long-form conversation to a congressional briefing, Blaise brings the same clarity, candor, and warmth to every room.

Featured conversation

Overcoming Self Hatred

Armchair Expert with Dax Shepard

Dr. Blaise Aguirre resting his chin on a stack of his books, including I Hate Myself and DBT For Dummies

Books & Ideas

Published Work

Blaise writes the way he speaks: rigorous in substance, generous in tone, and built to be useful to the people who need it most.

  • I Hate MyselfSelf-criticism
  • DBT For DummiesSkills & practice
  • DBT Workbook For DummiesSkills & practice
  • Borderline Personality Disorder in Adolescents3rd Edition

About Blaise

Scientific rigor, delivered with warmth and humor.

Dr. Blaise Aguirre is an internationally recognized psychiatrist, author, educator, and speaker whose work sits at the intersection of neuroscience, emotional regulation, mindfulness, and human behavior.

He is the Founding Medical Director of the 3East DBT Continuum at McLean Hospital, The Michael Hollander, PhD, Endowed Director, and an Assistant Professor in Psychiatry at Harvard Medical School.

Across decades of clinical work, Blaise has worked with people experiencing some of the most intense forms of emotional suffering. That experience informs a speaking style that combines scientific rigor with warmth, humor, practical tools, and an unusually deep understanding of what it means to be human.

His work with Harvard Medical School Executive Education translates these same ideas into leadership and organizational settings, helping executives and teams better understand how the brain responds to stress, uncertainty, connection, identity, and change.

Dr. Blaise Aguirre with an exaggerated surprised expression, holding a stack of his books

Speaking formats

Available For

In person or virtual, from the main stage to the boardroom.

  • Keynotes
  • Executive Leadership Sessions
  • Corporate Events
  • Healthcare & Medical Conferences
  • Workshops
  • Customized Conversations

Speaking inquiries

Inquire about Blaise

Tell us a little about your event. Approximate details are completely fine. Every engagement begins with a conversation, so the session fits your audience, your goals, and your moment.

Prefer email? Reach our booking team at booking@432ent.com.

Which topic are you most interested in?
Preferred Format

Your inquiry goes directly to the 432 Entertainment booking team.

432 Entertainment

Bring Blaise to your next event

For speaking inquiries and customized engagements:

432 Entertainment Valerie Sizemore booking@432ent.com

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